6.18 Conclusion
In this lab, we used genotype data from the 1000 Genomes Project to calculate two measures of population structure.
- We explored the Geography of Genetic Variants browser, a useful resource for visualizing allele frequency differences between human populations.
- Using genotype data from the 1000 Genomes Project, we plotted the allele frequency spectrum of variants in human populations.
- We saw that humans carry an excess of rare variation due to recent population expansion.
- We saw that humans carry an excess of rare variation due to recent population expansion.
- Finally, we used principal component analysis to cluster individuals in our dataset by their genotype information. Plotting individuals in PCA space allowed us to distinguish the five superpopulations of 1000 Genomes.