9.18 Top PBS hits

What are the top PBS hits we’ve identified? Click on the pbs table to scroll through the SNPs with the highest PBS values.

Use the UCSC Genome Browser to look up the top two PBS peaks. (We’re using the hg19 browser here because this data was generated with the hg19 reference genome.)

What genes (if any) do these top PBS peaks overlap with?

The top chr11 peak doesn’t seem to overlap with any genes, but is closest to KIRREL3.

The second chr11 peak overlaps with the fatty acid desaturase gene cluster (FADS1, FADS2, and FADS3), which have previously been implicated as targets of independent episodes of positive selection in human populations.

Fig. 8. The FADS gene cluster around the second PBS peak.