4 Linkage disequilibrium

In this module, we’ll use DNA sequencing data from human populations to assess linkage disequilibrium between two genetic variants.

4.0.0.1 Learning objectives

After completing this chapter, you’ll be able to:

1. Define linkage disequilibrium.
2. Manually calculate \(D\), \(D'\), and \(r^2\) from genotype data.
3. Understand the differences in interpretation for different LD statistics.
4. Explain how LD both benefits and limits genetics studies.

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